Live
- Jain Monk Shri 108 Jnaneshwar Muni Attains Samadhi at Devlapur
- Meet DJ Yogi: The Favorite DJ of Bollywood Celebrities and Sports Stars
- Synergy Marine Group Champions Onboard AI Agriculture for Healthier Crews and a Greener Future
- BJP alleges Rs 45 cr scam by AAP govt in school construction
- Yashoda Medicity organizes “Crown of Courage” ceremony to honor Cancer Survivors
- AAP appoints two-time legislator Arora as Punjab chief
- BJP won’t succeed in toppling Congress govt: K’taka Home Minister
- Turkey neutralises five Kurdish militants in Syria
- BJP questions Kejriwal on 21,000 deaths in Delhi due to contaminated water
- CM Revanth Reddy Inspects Progress of Telangana Mother Statue Installation
Researchers unveil biochemistry behind resilience of dengue eggs
Researchers from Indian Institute of Technology (IIT) Mandi and the Institute for Stem Cell Science and Regenerative Medicine in Bengaluru have discovered the biochemical processes that enable the eggs of the dengue-causing mosquito to survive harsh conditions and rejuvenate when favourable conditions return.
Shimla: Researchers from Indian Institute of Technology (IIT) Mandi and the Institute for Stem Cell Science and Regenerative Medicine in Bengaluru have discovered the biochemical processes that enable the eggs of the dengue-causing mosquito to survive harsh conditions and rejuvenate when favourable conditions return.
This research marks a significant stride in the battle against mosquito-borne diseases, offering hope for more effective vector control measures.
The details of this research have been published in the journal PLOS Biology.
The paper was co-authored by Baskar Bakthavachalu, Assistant Professor, School of Biosciences and Bioengineering, IIT Mandi, along with Anjana Prasad, Sreesa Sreedharan and Sunil Laxman from the Institute for Stem Cell Science and Regenerative Medicine (DBT-inStem).
Mosquitoes, viral vectors for various diseases, deposit their eggs in water, where they hatch. The eggs of dengue and Zika-carrying aedes mosquitoes can endure extended periods without water, akin to plant seeds patiently waiting for germination in the absence of moisture.
Despite the knowledge of this phenomenon, the molecular reasons behind the desiccation tolerance and post-rehydration survival remained a mystery until now.
The collaborative team reared Aedes aegypti mosquitoes, studying their eggs through a series of innovative experiments.
By subjecting the eggs to dehydration and subsequent rehydration, they discovered the developing larvae undergo specific metabolic changes required for survival.
Bakthavachalu, the lead researcher from IIT Mandi, explained, "Life is fundamentally dependent on water. However, extreme environmental conditions have allowed organisms to find ways to survive without water.
"Each of these organisms finds its own unique way to overcome water loss. Our understanding of this fundamental process remains limited. Mosquito eggs, facing drying conditions, enter an altered metabolic state to significantly increase the production of polyamines, which play a crucial role in enabling the embryos to withstand the damage caused by water loss."
Furthermore, they utilise high-calorie lipids as an energy source to complete their development once they are rehydrated, he said.
The implications of this research are far-reaching.
Understanding these survival mechanisms provides a foundation for innovative mosquito control strategies.
By disrupting the desiccation tolerance of mosquito eggs, researchers anticipate a significant reduction in mosquito populations and disease transmission. The understanding gained from this work could potentially prevent the resurgence of mosquitoes following monsoon rains, a period traditionally associated with increased disease transmission risks.
